Myocardial Infarction Genetic Database

Gene information

Official symbol	COL18A1
Official full name	collagen type XVIII alpha 1 chain
Gene type	protein-coding gene
Chromosome	21q22.3
Alias symbol	KS; KNO1
Previous symbol	KNO
Gene family	Collagens; MicroRNA protein coding host genes
Resources
Entrez Gene	80781
HGNC	HGNC:2195
Ensembl	ENSG00000182871
Vega	OTTHUMG00000090407
UCSC	uc062awh.1

GO terms: 23 records

GO	Description	Category	LogP	Number of genes	Detail
GO:0000902	cell morphogenesis	GO Biological Processes	-11.5134430	38	More
GO:0000904	cell morphogenesis involved in differentiation	GO Biological Processes	-8.70147397	29	More
GO:0001525	angiogenesis	GO Biological Processes	-32.8794581	74	More
GO:0001568	blood vessel development	GO Biological Processes	-43.2646440	106	More
GO:0001944	vasculature development	GO Biological Processes	-42.3240404	107	More
GO:0002064	epithelial cell development	GO Biological Processes	-8.05661081	27	More
GO:0003158	endothelium development	GO Biological Processes	-13.1102461	25	More
GO:0003382	epithelial cell morphogenesis	GO Biological Processes	-1.88179987	5	More
GO:0005198	structural molecule activity	GO Molecular Functions	-7.51921139	30	More
GO:0005201	extracellular matrix structural constituent	GO Molecular Functions	-12.8379048	20	More
GO:0005581	collagen trimer	GO Cellular Components	-6.28484906	16	More
GO:0005604	basement membrane	GO Cellular Components	-9.30297759	21	More
GO:0005788	endoplasmic reticulum lumen	GO Cellular Components	-47.2996164	57	More
GO:0007601	visual perception	GO Biological Processes	-1.33616096	7	More
GO:0008285	negative regulation of cell population proliferation	GO Biological Processes	-53.5569125	147	More
GO:0030020	extracellular matrix structural constituent conferring tensile strength	GO Molecular Functions	-4.38480829	9	More
GO:0030312	external encapsulating structure	GO Cellular Components	-73.3689453	93	More
GO:0030855	epithelial cell differentiation	GO Biological Processes	-14.2408795	69	More
GO:0031012	extracellular matrix	GO Cellular Components	-73.4416071	93	More
GO:0035239	tube morphogenesis	GO Biological Processes	-44.2569269	123	More
GO:0048514	blood vessel morphogenesis	GO Biological Processes	-39.8784810	93	More
GO:0050953	sensory perception of light stimulus	GO Biological Processes	-1.30130153	7	More
GO:0062023	collagen-containing extracellular matrix	GO Cellular Components	-67.6170082	80	More

Drug-Gene interaction

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Related drugs: 8 records

Drug name	Source	PMID	View
aspirin	NCI	11353854	view
camptothecin	NCI	15069724	view
celecoxib	NCI	12232050	view
collagenase clostridium histolyticum	ChemblInteractions		view
glutamine	NCI	16572858	view
ocriplasmin	ChemblInteractions		view
tamoxifen	NCI	16651433	view
thrombin	NCI	15615851	view

Related studies: 4 records

Molecular factor	Omics type	Objective	MI type	Reference
Chr21:45480753 hypermethylation	epigenomics	ischemic cardiac events[prognosis (bad)]	myocardial infarction	Thunders M et al. Epigenetics. 2019
collagen alpha-1(XVIII) chain	proteomics	reperfusion therapy[treatment (other)]	acute myocardial infarction	Seko Y et al. Clin Sci (Lond). 2004
collagen alpha-1(XVIII) chain	proteomics	acute myocardial infarction[diagnosis]	acute myocardial infarction	Ruge T et al. Scand Cardiovasc J. 2018
collagen alpha-1(XVIII) chain	proteomics	acute myocardial infarction[diagnosis]	acute myocardial infarction	Iribarren C et al. Vasc Med. 2006